Selenium deficiency in combination with Coxsackievirus infection can lead to Keshan disease, which is potentially fatal. Selenium deficiency also contributes (along with iodine deficiency) to Kashin-Beck disease. The primary symptom of Keshan disease is myocardial necrosis, leading to weakening of the heart. Keshan disease was endemic in Dechang but occurred rarely in Mianning. Researchers believe this happened in the cases of Keshan disease, which gained attention after affecting a region of China where the soil was particularly deficient in selenium. areas, mortality from Keshan disease dramatically decreased, but clinically latent cases were still found, and the echocardiographic prevalence of the disease remained high.2 Therefore, selenium deficiency seems to be a predisposing factor rather than a specific cause of Keshan disease… The amount of selenium in food … Keshan Disease Selenium. Selenium deficiency is rare, even in New Zealand and Finland, where selenium intake is much lower than in the United States and Canada. Keshan Disease, Selenium Deficiency, and the Selenoproteome. Asia Pac J Clin Nutr. 2011 Apr33(2):183-8. doi: 10.1007/s10653-010-9331-9. Keshan disease occurs only in selenium-deicient children and is associated with an enlarged heart and poor heart function. For example, selenium deficiency in combination with a second stress (possibly a viral infection) leads to Keshan disease, a cardiomyopathy that occurred in parts of China prior to a government-sponsored selenium supplementation program that began in the 1970s [ 2, 5, 8, 21 ]. Lastly, myxedematous endemic cretinism, a … Keshan disease is a congestive cardiomyopathy probably caused by dietary deficiency of selenium, named after Keshan, where symptoms were first noted. Extensive cross-sectional epidemiological studies showed that low selenium concentrations in cereal grains and low selenium status of local residents were associated with the occurrence of Keshan disease. This is a review article telling a 50-years old story about the studies on selenium deficiency and Keshan disease in China, an endemic heart disease with high case-fatality, as an example of translational research. It is named for the northeastern Chinese county Keshan, where the disease prevalence is high because of selenium-deficient soil. The second controversial disease is Keshan disease. Keshan disease is an inflammation of the heart muscle that causes a hearth illness known as cardiomyopathy. These symptoms were later found prevalent in young women and children in a wide belt extending from northeast to southwest China, a region with a selenium-deficient soil. Keshan disease damages the walls of the heart, resulting in cardiomyopathy. Abstract. Healthy boys and men (19-22 per group) from a low selenium area (Dechang County) and from an area where sodium selenite was added to salt (Mianning County) were studied. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang province, Northeast China, where symptoms were first noted. Selenium deficiency in combination with Coxsackievirus infection can lead to Keshan disease, which is potentially fatal. The efficacy of long-term selenium supplementation in the treatment of chronic Keshan disease with congestive heart failure is inconclusive. Selenium deficiency refers to not having enough selenium in your system. Keshan disease, an endemic cardiomyopathy occurring in low-selenium areas of China, was reported... Selenium. The earliest of these to be recognized was Keshan disease, a cardiomyopathy in selenium-poor parts of China, which was preventable by provision of oral selenium … Keshan disease was first described in Chinese medical literature more than 100 years ago, but not until 40 years after its widespread occurrence in 1935 was it discovered that selenium deficiency was an important factor in its aetiology (3). Selenium deficiency has been extensively studied in China, which has populations ranging from the lowest to the highest selenium levels in the world. KD is a gene-environment interaction disease. Keshan disease is a deficiency condition caused by the dietary deficiency of selenium. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang province, Northeast China, where symptoms were first noted. Geologists investigating the soil conditions of the Keshan county in Northeast China discovered that a serious cardiomyopathy (heart disease) was a result of selenium deficiency. 4 The patient with Crohn’s disease … Keshan disease, an endemic cardiomyopathy occurring in low-selenium areas of China and Russia, is associated... SELENIUM | Physiology. Selenium has low concentrations in most New Zealand soils, but there has been little indication that the low intake has resulted in any detrimental effects on the health of New Zealanders. In the area, a disproportionate number of people got heart failure until the inhabitants began to be Supplemented with Selenium; whereupon the cases of heart failure dramatically declined. Keshan disease (KD) is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. Kashin-Beck disease is a disorder of the bones and joints of the hands and ingers, elbows, knees, and ankles of children and adolescents. Keshan disease (KD) is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. As China has geographical regions known to have either extremely high or low soil selenium levels, one of the first human diseases associated with selenium deficiency was identified there, in a region of Heilongjiang province named Keshan. 2 Similar cases of cardiomyopathy were reported in HIV-infected patients 3 and in subjects on parenteral nutrition. This is a review article telling a 50-years old story about the studies on selenium deficiency and Keshan disease in China, an endemic heart disease with high case-fatality, as an example of translational research. List of authors. Keshan disease is a disease of heart muscle (congestive cardiomyopathy) which is potentially fatal. Keshan disease … Named after the two Russian scientists who first described the disease in the mid-1800s (Fordyce). This disease may be more common in Siberia and China. SELENIUM TOXICITY: Selenium toxicity is a much more rare occurrence than selenium deficiency. Keshan Disease, Selenium Deficiency, and the Selenoproteome Joseph Loscalzo, M.D., Ph.D. Investigation of a muscle disease in animals and a cluster of … The story of selenium and antiviral immunity began in China in the 1960s. Selenium deficiency and iodine deficiency are also considered common in people affected by Keshan disease, a cardiovascular disease, and Kashin-Beck disease, a chronic bone, joint and cartilage disorder that is most prevalent in parts of Asia. It was first noted in the Keshan province in Heilongjiang, China. The questionable selenium deficiency is Keshan disease. The primary symptom of Keshan disease is myocardial necrosis, … Kashin-Beck Disease can commonly be found in the same region as Keshan Disease, in the northern part of China (Fordyce). Chen J; An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). KD is a gene–environment interaction disease. Abstract. Below is a topographical map of China to give you an idea of what areas are mountainous. A selenium deficiency could cause you to develop Kashin-Beck disease, a joint and bone disorder that is geographically concentrated in parts of central China, eastern Siberia, and northern Korea. Since the discovery of the essentiality of selenium (Se) for rats by Schwarz and Foltz (1957) and for chicks by Patterson et al. Selenium deficiency is rare, even in New Zealand and Finland, where selenium intake is 30 to 50 mcg/day, compared with 100 to 250 mcg/day in the US and Canada. Severe deficiencies of selenium are associated with a rare but fatal form of heart disease called Keshan disease. Selenium is a trace mineral needed for proper thyroid function and other processes. This is so well known that it is called Keshan disease after a province in China that has very low levels of selenium in the soil. This disease occurred primarily in the mountainous regions of China, causing heart lesions. Selenium is an antioxidant in the enzyme selenium-glutathione peroxidase. In certain areas of China where selenium intake is even lower, people with selenium deficiency are more likely to develop Keshan disease, a viral disease that affects mainly children and young women. Environ Geochem Health. Because of that factor, Keshan deficiency can be found anywhere that the level of selenium present in the soil is low. An individual with Keshan disease will have an abnormally large heart. Keshan disease can also lead to higher rates of cancer, cardiovascular disease, hypertension, and strokes. Lei C, Niu X, Ma X, et al; Is selenium deficiency really the cause of Keshan disease? The wide range of biochemical and physiologic functions inevitably has led to a variety of presentations of selenium deficiency. This can cause several health problems. It was later found to be prevalent in a wide belt extending from Southwest to Northeast China. KD is mainly distributed in a selenium-deficient zone from northeast to … This study aimed to determine whether selenium supplementation is associated with a decreased risk of cardiac death in chronic Keshan disease with congestive heart failure by ten years of follow-up. 201221(3):320-6. Keshan disease is a disease related to selenium deficiency in endemic regions of China, which results in congestive cardiomyopathy, heart failure, cardiomegaly, and ECG changes. Selenium deficiency was identified as a factor in the etiology of heart failure syndromes in areas of very low selenium intakes, such as China, where an endemic selenium-responsive cardiomyopathy is called Keshan disease. Figure 9.421 Topographical map of China 2. Selenium Deficiency and Keshan Disease. Keshan disease is an illness that is a direct result of a deficiency in the mineral selenium. However, in combination with other health issues, it has been shown to be linked with selenium deficiency6. While selenium deficiency is a major etiological factor of Keshan disease, the seasonal and annual variation in disease occurrence suggested that other factors, especially an infectious agent, might be involved in addition to selenium deficiency . This is a review article telling a 50-years old story about the studies on selenium deficiency and Keshan disease in China, an endemic heart disease with high case-fatality, as an example of translational research. A deficiency of selenium in an area of China has resulted in an endemic form of cardiomyopathy, called Keshan disease. 12 Symptoms of the disease include: This disease is caused by selenium deficiency combined with infection with coxsackievirus (the virus responsible for hand, foot, and mouth disease). This disease occurred primarily in the mountainous regions of China, causing heart lesions. Here, we used stepwise multiple regression analysis to analyze the risk factors of the disease and the … Doctors suspect selenium deficiency based on the person’s circumstances and symptoms. Blood tests for this deficiency are not readily available. Treatment with a selenium supplement may result in a complete recovery. Taking selenium supplements can prevent but not cure cardiomyopathy due to Keshan disease. Selenium deficiency is necessary for the development of the cardiomyopathy known as Keshan disease. In certain areas of China where selenium intake is even lower, people with selenium deficiency are more likely to develop Keshan disease, a viral disease that affects mainly children and young women. Keshan disease damages the walls of the heart, resulting in cardiomyopathy. It was named after the location where it was first identified: Keshan County in China. These symptoms were later found prevalent in a wide belt extending from northeast to southwest China, all due to selenium … Specifically, selenium deficiency alone cannot cause the occurrence of this disease. These symptoms were later found prevalent in a wide belt extending from northeast to southwest China, all due to selenium … Selenium deficiency also contributes (along with iodine deficiency) to Kashin-Beck disease. Keshan disease. Keshan disease (KD) is an endemic cardiomyopathy with myocardial lesions for which the precise etiology has not been determined. The discovery that the juvenile cardiomyopathy known as Keshan disease likely has a dual etiology that involves both a nutritional deficiency of the essential trace mineral selenium (Se) as well as an infection with an enterovirus provided the impetus for additional studies of relationships between nutrition and viral infection. Growing children with selenium deficiency may develop a slowly progressive, disabling disorder of the joints and bone (Kashin-Beck disease). One of the selenium-deficient regions in China is Keshan county, which is the locus of a serious cardiomyopathy that has been dubbed Keshan disease. It is named for the northeastern Chinese county Keshan, where the disease prevalence is high because of selenium-deficient soil. Evidence that selenium protects against viral infections . It is often triggered by the presence of Coxsackievirus or some chemical trigger. Notably, severe selenium deficiency in humans is associated with a rare but fatal form of dilated cardiomyopathy (DCM) that is restricted to specific geographic regions (Keshan disease) that …
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